2019 MRS Fall Meeting & Exhibit

Symposium SB06 : Bringing Mechanobiology to Materials—From Molecular Understanding to Biological Design

2019-12-02   Show All Abstracts

Symposium Organizers

Christine Selhuber-Unkel, University of Kiel
Jennifer Curtis, Georgia Institute of Technology
Matthew Paszek, Cornell University
Kate Poole, University of New South Wales

Symposium Support

Bronze
TA Instruments
SB06.01: Cells as Mechanosensory Living Materials I
Session Chairs
Christine Selhuber-Unkel
Ana-Sucana Smith
Monday AM, December 02, 2019
Hynes, Level 2, Room 201

8:30 AM - SB06.01.01
Sensing Local Strains in the Cytoskeleton via LIM Domains

Patrick Oakes1

Loyola University Chicago Stritch School of Medicine1

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9:00 AM - SB06.01.02
Mechanical Manipulation of Tandem Repeats of Biological Motifs—One Molecule at a Time

Jaba Mitra1,2,Taekjip Ha2

University of Illinois at Urbana-Champaign1,Johns Hopkins University2

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9:15 AM - SB06.01.03
Biologically Inspired, Cell–Selective Release of Aptamer–Trapped Growth Factors by Traction Forces

Benjamin Almquist1

Imperial College London1

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9:30 AM - SB06.01.04
Watching Cellular Mechanotransduction—Piezo1 Activation by Cellular Traction Forces

Medha Pathak2,Kyle Ellefsen1,Jesse Holt2,Alice Chang3,Jamison Nourse2,Janahan Arulmoli2,Armen Mekhdjian3,Hamid Abuwarda2,Francesco Tombola2,Lisa Flanagan2,Alexander Dunn3,Ian Parker1

University of California1,University of California, Irvine2,Stanford University3

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10:00 AM -
BREAK


10:30 AM - SB06.01.05
From Microdishes to Microniches—Controlling Single Cell Apico-Basal Polarity and Lumenogenesis

Virgile Viasnoff1,2,Yue Zhang1,Richard deMets1,Celine Stoecklin1

National University of Singapore1,Centre National de la Recherche Scientifique2

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11:00 AM - SB06.01.06
Mechanism in Collective Organizations of Living Cells

Joachim Spatz1

Max Planck Institute for Medical Research1

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11:30 AM - SB06.01.07
Soft Tissue Mechanics Result from Fibrous Networks Confined by Close-Packed Cells

Paul Janmey1,Anne van Oosten1,2,Xingyu Chen1,Vivek Shenoy1

University of Pennsylvania1,Leiden University2

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SB06.02: Cell Adhesion and Mechanics
Session Chairs
Christine Selhuber-Unkel
Britta Trappmann
Monday PM, December 02, 2019
Hynes, Level 2, Room 201

1:30 PM - SB06.02.01
Single-Molecule Measurements of Force Transmission by Integrin Heterodimers in Living Cells

Alexander Dunn1

Stanford University1

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2:00 PM - SB06.02.02
Multiscale Modeling of the Facet Capsule Ligament—Size Effects and Problem Size Reduction through Generalized Boundary Conditions

Jacob Merson1,Catalin Picu1

Rensselaer Polytechnic Institute1

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2:15 PM - SB06.02.03
Towards Non-Optical, Label-Free Measurements of Particle and Cell Stiffness in Flow

Charles Dhong1,Darren Lipomi2

University of Delaware1,University of California, San Diego2

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2:30 PM - SB06.02.04
Local Catalytic Effects in Adherent Membranes

Ana-Sucana Smith1

FAU Erlangen-Nürnberg1

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3:00 PM -
BREAK


SB06.03: Tools to Study Mechanotransduction
Session Chairs
Matthew Paszek
Medha Pathak
Monday PM, December 02, 2019
Hynes, Level 2, Room 201

3:30 PM - SB06.03.01
Synthetic Extracellular Matrices to Study Mechanotransduction in 3D

Britta Trappmann1

Max Planck Institute for Molecular Biomedicine1

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4:00 PM - SB06.03.02
A Sensitive Tool for Probing Cellular Mechanics—Tracking Longitudinal Rotation with a Kinked-Silicon Nanowire

Youjin Lee1,David Wu1,Yuxing Peng1,Bozhi Tian1

The University of Chicago1

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4:15 PM - SB06.03.03
NIR-Actuated Composites to Perturb and Profile Mechano-Chemical Cell Signaling

Rachel Steinhardt1,Nicholas Vishnosky1

Syracuse University1

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4:30 PM - SB06.03.04
A Materials Approach to Studying Forces, Form and Function in Cells and Tissues

Christopher Chen1,2

Boston University1,Harvard University2

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SB06.04: Poster Session I: Bringing Mechanobiology to Materials—From Molecular Understanding to Biological Design I
Session Chairs
Monday PM, December 02, 2019
Hynes, Level 1, Hall B

8:00 PM - SB06.04.01
Towards the Development of a Macroscopic, Biohybrid, Hydrogel-Based Actuator

Christine Arndt1,Mohammadreza Taale1,Florian Ceynowa1,Fabian Schuett1,Rainer Adelung1,Christine Selhuber-Unkel1

Kiel University1

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8:00 PM - SB06.04.02
Detachment of the Biomolecule Bindings between the Microtubules and Kinesins

Kenta Hatazawa1,Ryuzo Kawamura2,Takayuki Hoshino1

Hirosaki University1,Saitama University2

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8:00 PM - SB06.04.03
Behavior and Phenotype of Cancer Cells in Response to Varied Mechanical Environment in 3D Hydrogel Models Cultured In Vitro

Jason Nichol1,Tayler Laycox1,Riley Aspinwall1,Ian Schmidt1

Endicott College1

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8:00 PM - SB06.04.04
The Signaling Response of Artificial Neurons Made from Chemical Oscillators

James Sheehy1,Seth Fraden1

Brandeis University1

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8:00 PM - SB06.04.05
Characterizing Hetero-Oligomers from Amyloid-Beta and Alpha-Synuclein with AFM

Eun Ji Shin1,Joon Won Park1

Pohang University of Science and Technology1

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8:00 PM - SB06.04.06
Designed Liquid Crystalline Polypeptide Fibres

Hannah Leese2,1,James MacDonald1,Karan Bali1,Paul Freemont1,Milo Shaffer1

Imperial College London1,University of Bath2

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8:00 PM - SB06.04.07
Cortex Dominates Bacillus subtilis Spore’s Water-Responsive Behaviors

Zhi-Lun Liu1,Haozhen Wang1,Xi Chen1

The City University of New York1

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8:00 PM - SB06.04.08
Understanding the Molecular Mechanism of Cartilage Degradation and Cation Channel Activity

Deng Li1,Kai-Chih Yeh1,Yuan Chiang1,Shu-Wei Chang1

National Taiwan University1

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8:00 PM - SB06.04.09
Nanofibrils as Basic Building Blocks of Natural Spider Silk

Qijue Wang1,Chloe Walsh1,Dinidu Perera1,Hannes Schniepp1

College of William and Mary1

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8:00 PM - SB06.04.10
Influence of Different Mechanical Conditions on Cell Behavior

Sandra Sindt1,Yasmeen El-Rayyes1,Galen Ream1,Christine Selhuber-Unkel1

Kiel University1

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8:00 PM - SB06.04.11
Rapid Magnetic Printing of 3D Cell Structures

Sarah Mishriki1,Abdel Rahman Abdel Fattah1,2,Tobias Kammann1,3,Srivatsa Aithal1,Rakesh Sahu1,Fei Geng1,Ishwar Puri1

McMaster University1,KU Leuven2,Friedrich-Schiller-University3

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8:00 PM - SB06.04.12
Design of Novel Scaffolds for Effective Healing of Bone Fractures Using Topology Optimization Based on Mechano-Biological Model, Angiogenesis and Scaffold Degradation

Mervenaz Sahin1,Mehmet Serhat Aydin1,Gullu Kiziltas Sendur1,2

Sabanci University1,Sabanci University Nanotechnology Research and Application Center2

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8:00 PM - SB06.04.13
Modulation of Chemical Reactivity by Strong Coupling to Molecular Vibrations

Wonmi Ahn1,2,Igor Vurgaftman2,Adam Dunkelberger2,Jeffrey Owrutsky2,Blake Simpkins2

Excet Inc.1,U.S. Naval Research Laboratory2

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2019-12-03   Show All Abstracts

Symposium Organizers

Christine Selhuber-Unkel, University of Kiel
Jennifer Curtis, Georgia Institute of Technology
Matthew Paszek, Cornell University
Kate Poole, University of New South Wales

Symposium Support

Bronze
TA Instruments
SB06.05: Hot Topics in Bringing Mechanobiology to Materials
Session Chairs
Matthew Paszek
Christine Selhuber-Unkel
Tuesday AM, December 03, 2019
Hynes, Level 2, Room 201

8:00 AM - SB06.05.01
Nanowire-Based Spatio-Mechano-Chemical Guidance of the Cell Immune Activity

Mark Schvartzman1,Viraj Bhingardive1,Guillaume Le Saux1

Ben-Gurion University of the Negev1

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8:15 AM - SB06.05.02
Extracellular Matrix Plasticity as a Driver of Cell Spreading

Joshua Grolman1,Philipp Weinand1,David Mooney1

Harvard University1

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8:30 AM - SB06.06.01
Photoresponsive Materials for Resolving Mechanobiology in Collective Cell Migration

Jun Nakanishi1

National Institute for Materials Science1

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9:00 AM - SB06.06.02
Dynamic, Reversible Control of Biomaterial Properties Using DNA

Nicholas Stephanopoulos1

Arizona State University1

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9:15 AM - SB06.06.03
Design and Development of Mechanobiological Gels That Can Control Mechanical Property

Takeshi Ueki1,Ryota Tamate1,Aya Akimoto2,Ryo Yoshida2,Jun Nakanishi1

National Institute for Materials Science1,The University of Tokyo2

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9:30 AM - SB06.06.04
Building with Cells—Exploiting Mechanobiology to Use Living Cells as an Engineering Material

Kevin Kit Parker1

Harvard University1

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10:00 AM -
BREAK


SB06.07: Bioinspired and Biofunctional Materials
Session Chairs
Cornelia Lee-Thedieck
Angela Pitenis
Tuesday AM, December 03, 2019
Hynes, Level 2, Room 201

10:30 AM - SB06.07.01
Bioinspired Materials for Deconstructing Matrix Structure-Cell Function Relationships

Kristopher Kilian1

University of New South Wales1

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11:00 AM - SB06.07.02
The Adaptive Behavior of Cells as Archetype for Novel Strain-Stiffening Structures

Michael Timmermann1,Leonard Siebert1,Rainer Adelung1,Christine Selhuber-Unkel1

University of Kiel1

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11:15 AM - SB06.07.03
Stiff and Responsive Hybrid Bacterial Assemblies through Covalent Crosslinking of Nanoparticles to Engineered Bacterial S-Layer Proteins

Dong Li1,Marimikel Charrier1,Sneha Jani1,Behzad Rad1,Bruce Cohen1,Kathleen Ryan2,Caroline Ajo-Franklin1,Paul Ashby1

Lawrence Berkeley National Laboratory1,University of California, Berkeley2

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11:30 AM - SB06.07.04
Microfluidic Fabrication of Asymmetric Lipid and Polymer Vesicles

Yuting Huang1,David Weitz1

Harvard University1

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SB06.08: Synthetic Mechanoresponsive Materials
Session Chairs
Patrick Oakes
Matthew Paszek
Tuesday PM, December 03, 2019
Hynes, Level 2, Room 201

1:30 PM - SB06.08.01
Force Amplification in Mechanochemically Active Polymers

Nancy Sottos1,Tae Ann Kim1,Jaeuk Sung1,Jeffrey Moore1

University of Illinois at Urbana-Champaign1

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2:00 PM - SB06.08.02
Engineering Elasticity Inspired by Natural Biopolymers

Anna Tarakanova1

University of Connecticut1

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2:15 PM - SB06.08.03
Morphogenic Patterning in Synthetic Polymers

Evan Lloyd1,2,Adam Feinberg1,2,Philippe Geubelle1,2,Nancy Sottos1,2,Jeffrey Moore1,2

University of Illinois at Urbana-Champaign1,Beckman Institute for Advanced Science and Technology2

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2:30 PM - SB06.08.04
Embodied Intelligence and Energy in Autonomous Matter

Rob Shepherd1

Cornell University1

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3:00 PM -
BREAK


SB06.09: Soft Materials for Biomedicine
Session Chairs
Alexander Dunn
Patrick Oakes
Tuesday PM, December 03, 2019
Hynes, Level 2, Room 201

3:30 PM - SB06.09.01
Cells, Gels and Shear—Designing Soft Materials for Biomedicine

Angela Pitenis1

University of California, Santa Barbara1

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4:00 PM - SB06.09.02
Mechanically Tunable Structured Hydrogels and Their Impact on Cells

Katharina Siemsen1,Chanh Hu Trinh1,Florian Ceynowa1,Rainer Adelung1,Jan Lammerding2,Christine Selhuber-Unkel1

Kiel University1,Cornell University2

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4:15 PM - SB06.09.03
Hyper-Activation of Cellular Rigidity Sensing Pathways by the Surface Tension of Biomedical Silicones

Zhu Cheng1,Carolyn Shurer1,Samuel Schmidt1,Vivek Gupta1,Grace Chuang1,Jin Su1,Amanda Watkins1,Jason Spector1,Chung-Yuen Hui1,Heidi Reesink1,Matthew Paszek1

Cornell University1

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4:30 PM - SB06.09.04
Mechanobiology in the Hematopoietic Stem Cell Niche

Cornelia Lee-Thedieck1

Leibniz University Hannover1

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2019-12-04   Show All Abstracts

Symposium Organizers

Christine Selhuber-Unkel, University of Kiel
Jennifer Curtis, Georgia Institute of Technology
Matthew Paszek, Cornell University
Kate Poole, University of New South Wales

Symposium Support

Bronze
TA Instruments
SB06.10/SB09.08: Joint Session: Mechanics of Cancer Invasion
Session Chairs
Ming Guo
Jan Lammerding
Susan Leggett
Ian Wong
Wednesday AM, December 04, 2019
Hynes, Level 3, Room 304

8:30 AM - SB06.10.01/SB09.08.01
Cell-Matrix Interactions in Cancer and Fibrosis—Multiscale Chemo-Mechanical Models

Vivek Shenoy1

University of Pennsylvania1

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9:00 AM - SB06.10.02/SB09.08.02
Biomechanical Imaging of Cancer Cells and Tumor Development in 3D

Ming Guo1

Massachusetts Institute of Technology1

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9:30 AM - SB06.10.03/SB09.08.03
3D Traction Force Microscopy of Multicellular Invasion in Biomimetic Silk-Collagen Hydrogels

Susan Leggett1,Mohak Patel1,Thomas Valentin1,Christian Franck2,Ian Wong1

Brown University1,University of Wisconsin–Madison2

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9:45 AM - SB06.10.04/SB09.08.04
Unjamming and Collective Migration in MCF10A Series of Breast Cancer Cell Lines

Jae Hun Kim1,Jeffrey Fredberg1

Harvard University1

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10:00 AM -
BREAK


10:30 AM - SB06.10.05/SB09.08.05
Mechanical Forces, the Microenvironment and Metastasis of 3D Microtumors

Bryan Nerger2,Joe Tien1,Celeste Nelson2

Boston University1,Princeton University2

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11:00 AM - SB06.10.06/SB09.08.06
Engineered Microfluidic Environments to Study the Role of Nuclear Mechanobiology in Cancer Progression

Jan Lammerding1

Cornell University1

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11:30 AM - SB06.10.07/SB09.08.07
The National Cancer Institute’s Support for the Interface of Bio/Nano Materials with Cancer Research

Nas Zahir1

National Cancer Institute1

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SB06.11/SB09.09: Joint Session: Cancer Cell—ECM Interactions
Session Chairs
Sidi Bencherif
Matthew Paszek
John Slater
Nas Zahir
Wednesday PM, December 04, 2019
Hynes, Level 3, Room 304

1:30 PM - SB06.11.01/SB09.09.01
Nuclear Rupture at High Curvature and High Rates Upsets DNA Repair to Affect Cell Cycle, Differentiation and Genome Variation

Dennis Discher1

University of Pennsylvania1

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2:00 PM - SB06.11.02/SB09.09.02
The Dynamic and Reciprocal Relationship between Tissue Tension and Pro Tumor Immunity

Valerie Weaver1

University of California, San Francisco1

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2:30 PM -
BREAK


3:30 PM - SB06.11.03/SB09.09.03
Biosynthetic Hydrogels for Islet Engraftment and Immune Acceptance

Andres Garcia1

Georgia Institute of Technology1

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4:00 PM - SB06.11.04/SB09.09.04
Viscoelasticity and Cancer

David Mooney1

Harvard University1

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4:30 PM - SB06.11.05/SB09.09.05
Integrin-Specific Hydrogels Direct Mesenchymal Stem Cell Immunomodulation and Bone Regeneration

Karen Martin1,Amy Clark1,José García1,Christopher Johnson1,2,Hannah Theriault1,Woojin Han1,Dennis Zhou1,Edward Botchwey1,2,Andres Garcia1

Georgia Tech1,Emory University2

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SB06.12: Poster Session II: Bringing Mechanobiology to Materials—From Molecular Understanding to Biological Design II
Session Chairs
Wednesday PM, December 04, 2019
Hynes, Level 1, Hall B

8:00 PM - SB06.12.01
Elucidating the Effects of Direct Physical Contact between Dental Pulp Stem Cells Cultivated on Polybutadiene with Different Stiffness on Proliferation and Differentiation Behaviors

Yihan Shen1,Zijian Ma2,Ya-Chen Chuang3,4,Jessica Hofflich3,Miriam Rafailovich3,Marcia Simon3

St. Andrew's School1,Tianjin Nankai High School2,Stony Brook University3,ThINC Facility, Advanced Energy Center4

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8:00 PM - SB06.12.02
Bio-Inspired and Bio-Mimetic Self-Assembled Materials

Sharon Gilead1,Ehud Gaizt1

Tel Aviv University1

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8:00 PM - SB06.12.03
Investigating Substrate Mechanics Effects in Combination with TiO2 Thin Layer Coated by Atomic Layer Deposition (ALD) for Dental Pulp Stem Cell Proliferation and Differentiation

Megha Gopal1,Jessica Hofflich2,Ya-Chen Chuang2,Miriam Rafailovich2

New Hyde Park Memorial High School1,Stony Brook University, The State University of New York2

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8:00 PM - SB06.12.04
Shape Memory Cell Culture Platform for Mechanobiology

Koichiro Uto1,Mitsuhiro Ebara1

National Institute for Materials Science1

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8:00 PM - SB06.12.05
Engineering Tubular Structured Epithelial Organoids by Directed Tissue Assembly

Yan Yan Shery Huang1,Ye Liu1,Joo-Hyeon Lee1,Catherine Dabrowska1

University of Cambridge1

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Symposium Support